Functional magnetic resonance imaging exploration of combined hand and speech movements in Parkinson's disease
Identifieur interne : 000174 ( France/Analysis ); précédent : 000173; suivant : 000175Functional magnetic resonance imaging exploration of combined hand and speech movements in Parkinson's disease
Auteurs : Serge Pinto [France] ; Laura Mancini [Royaume-Uni] ; Marjan Jahanshahi [Royaume-Uni] ; John S. Thornton [Royaume-Uni] ; Elina Tripoliti [Royaume-Uni] ; Tarek A. Yousry [Royaume-Uni] ; Patricia Limousin [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Acoustic Stimulation, Adult, Aged, Brain (blood supply), Brain (pathology), Brain (physiopathology), Brain Mapping, Exploration, Female, Functional Laterality, Functional imaging, Hand, Hand (physiopathology), Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging (methods), Male, Middle Aged, Movement (physiology), Nervous system diseases, Neuropsychological Tests, Nuclear magnetic resonance imaging, Oxygen (blood), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Photic Stimulation, Psychomotor Performance (physiology), Speech, dual task, functional magnetic resonance imaging, hand movement, speech production.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Brain.
- methods : Magnetic Resonance Imaging.
- pathology : Brain, Parkinson Disease.
- physiology : Movement, Psychomotor Performance.
- physiopathology : Brain, Hand, Parkinson Disease.
- Acoustic Stimulation, Adult, Aged, Brain Mapping, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, Photic Stimulation, Speech.
Abstract
Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients have specific difficulties performing two movements simultaneously. In 9 unmedicated patients with Parkinson's disease and 15 healthy control subjects, externally cued tasks (i.e., hand movement, speech production, and combined hand movement and speech production) were performed twice in a random order and functional magnetic resonance imaging detected cerebral activations, compared to the rest. F‐statistics tested within‐group (significant activations at P values < 0.05, familywise error corrected), between‐group, and between‐task comparisons (regional activations significant at P values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects, the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In patients with Parkinson's disease, only activations underlying hand movement were observed during the combined task. We interpreted this phenomenon as patients' potential inability to recruit facilitatory activations while performing two movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (i.e., hand movement), in comparison with the other (i.e., speech production). Our observation could also reflect the inability of patients with Parkinson's disease to intrinsically engage the motor coordination necessary to perform a combined task. © 2011 Movement Disorder Society
Url:
- https://api.istex.fr/document/7E42461455C59B1B37A4EF0EECE281E61FA5FABB/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184369
DOI: 10.1002/mds.23799
Affiliations:
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ISTEX:7E42461455C59B1B37A4EF0EECE281E61FA5FABBLe document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-10">2011-10</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2212">2212</biblScope><biblScope unit="page" to="2219">2219</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7E42461455C59B1B37A4EF0EECE281E61FA5FABB</idno><idno type="DOI">10.1002/mds.23799</idno><idno type="ArticleID">MDS23799</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation</term><term>Adult</term><term>Aged</term><term>Brain (blood supply)</term><term>Brain (pathology)</term><term>Brain (physiopathology)</term><term>Brain Mapping</term><term>Exploration</term><term>Female</term><term>Functional Laterality</term><term>Functional imaging</term><term>Hand</term><term>Hand (physiopathology)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Nuclear magnetic resonance imaging</term><term>Oxygen (blood)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Photic Stimulation</term><term>Psychomotor Performance (physiology)</term><term>Speech</term><term>dual task</term><term>functional magnetic resonance imaging</term><term>hand movement</term><term>speech production</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Hand</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Photic Stimulation</term><term>Speech</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Exploration</term><term>Imagerie RMN</term><term>Imagerie fonctionnelle</term><term>Main</term><term>Maladie de Parkinson</term><term>Parole</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson's disease, in which patients have specific difficulties performing two movements simultaneously. In 9 unmedicated patients with Parkinson's disease and 15 healthy control subjects, externally cued tasks (i.e., hand movement, speech production, and combined hand movement and speech production) were performed twice in a random order and functional magnetic resonance imaging detected cerebral activations, compared to the rest. F‐statistics tested within‐group (significant activations at P values < 0.05, familywise error corrected), between‐group, and between‐task comparisons (regional activations significant at P values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects, the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In patients with Parkinson's disease, only activations underlying hand movement were observed during the combined task. We interpreted this phenomenon as patients' potential inability to recruit facilitatory activations while performing two movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (i.e., hand movement), in comparison with the other (i.e., speech production). Our observation could also reflect the inability of patients with Parkinson's disease to intrinsically engage the motor coordination necessary to perform a combined task. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mancini, Laura" sort="Mancini, Laura" uniqKey="Mancini L" first="Laura" last="Mancini">Laura Mancini</name></region><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name><name sortKey="Mancini, Laura" sort="Mancini, Laura" uniqKey="Mancini L" first="Laura" last="Mancini">Laura Mancini</name><name sortKey="Mancini, Laura" sort="Mancini, Laura" uniqKey="Mancini L" first="Laura" last="Mancini">Laura Mancini</name><name sortKey="Thornton, John S" sort="Thornton, John S" uniqKey="Thornton J" first="John S." last="Thornton">John S. Thornton</name><name sortKey="Thornton, John S" sort="Thornton, John S" uniqKey="Thornton J" first="John S." last="Thornton">John S. Thornton</name><name sortKey="Tripoliti, Elina" sort="Tripoliti, Elina" uniqKey="Tripoliti E" first="Elina" last="Tripoliti">Elina Tripoliti</name><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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